During stoppage time — in overtime, no less — Uruguay's Luis Suarez was left with no choice but to commit a handball violation. Asamoah Gyan, who had made two PKs during the World Cup already, took it. He missed.
The game went to penalty kicks, and Uruguay escaped with the win. Gyan — who scored the game-winner against the the U.S. — now joins Robert Baggio in the pantheon of World Cup goats. To Wikipedia, everyone!