Cardinals starting pitcher Steven Matz allowed four runs on four hits and three walks in 4 1/3 innings
Dakota Hudson (1-0) threw 3 1/3 scoreless innings of relief to earn the victory.
Alex Call and CJ Abrams hit solo homers for the Nationals and Ildemaro Vargas hit a two-run double
Nationals starting pitcher Jake Irvin allowed four runs on six hits in three innings. Reliever Amos Willingham (0-1) took the loss
After rain delayed the start by more than an hour, the Cardinals broke out to a 4-0 lead in the second inning
Burleson led off the inning with a homer. Gorman singled, Ivan Herrera was hit by a pitch, Donovan laced a two-run triple and Paul Goldschmidt followed with an RBI single.
Matz retired his first seven hitters before allowing Call's solo homer. One out later, Abrams' homer cut the Washington deficit to 4-2.
The Nationals cut their deficit to 4-3 in the fourth inning. Vargas and Dominic Smith drew two-out walks and Riley Adams hit an RBI single
Washington tied the game in the fifth inning. Michael Chavis doubled, took third on a bunt and scored on Joey Meneses' sacrifice fly to the left-field wall.
But the Cardinals seized a 7-4 lead in the bottom of the inning. Jordan Walker and Burleson began the uprising with two-out singles, Gorman followed with a two-run double and Paul DeJong hit an RBI single
St. Louis made it 8-4 in the sixth inning. Goldschmidt led off with a double, moved to third base on Lars Nootbaar's single and scored on Arenado's sacrifice fly.
Arenado's eighth-inning homer made it 9-4, then Vargas cut the lead to three runs with his two-run double in the ninth.
Every Cardinals batter finished with at least one hit
--Field Level Media