Photo Credit: Patrick Semansky/AP

Since 1901.

  1. Nolan Ryan, 1973 (383 strikeouts)
  2. Sandy Koufax, 1965 (382 strikeouts)
  3. Randy Johnson, 2001 (372 strikeouts)
  4. Nolan Ryan, 1974 (367 strikeouts)
  5. Randy Johnson, 1999 (364 strikeouts)
  6. Rube Waddell, 1904 (349 strikeouts)
  7. Bob Feller, 1946 (348 strikeouts)
  8. Randy Johnson, 2000 (347 strikeouts)
  9. Nolan Ryan, 1977 (341 strikeouts)
  10. Randy Johnson, 2002 (334 strikeouts)
  11. Nolan Ryan, 1972 (329 strikeouts)
  12. Randy Johnson, 1998 (329 strikeouts)
  13. Nolan Ryan, 1976 (327 strikeouts)
  14. Sam McDowell, 1965 (325 strikeouts)
  15. Curt Schilling, 1997 (319 strikeouts)
  16. Sandy Koufax, 1966 (317 strikeouts)
  17. Curt Schilling, 2002 (316 strikeouts)
  18. Walter Johnson, 1910 (313 strikeouts)
  19. J.R. Richard, 1979 (313 strikeouts)
  20. Pedro Martinez, 1999 (313 strikeouts)
  21. Steve Carlton, 1972 (310 strikeouts)
  22. Mickey Lolich, 1971 (308 strikeouts)
  23. Randy Johnson, 1993 (308 strikeouts)
  24. Sandy Koufax, 1963 (306 strikeouts)
  25. Mike Scott, 1986 (306 strikeouts)
  26. Pedro Martinez, 1997 (305 strikeouts)
  27. Sam McDowell, 1970 (304 strikeouts)
  28. Walter Johnson, 1912 (303 strikeouts)
  29. J.R. Richard, 1978 (303 strikeouts)
  30. Rube Waddell, 1903 (302 strikeouts)
  31. Vida Blue, 1971 (301 strikeouts)
  32. Nolan Ryan, 1989 (301 strikeouts)
  33. Clayton Kershaw, 2015 (301 strikeouts)
  34. Chris Sale, 2017 (300 strikeouts and counting)
  35. Getting hit by a pitch
  36. Curt Schilling, 1998 (300 strikeouts)