Best MLB Bets for Monday, September 15th: Top Baseball Betting Picks Today

Kevin RogersKevin Rogers|published: Mon 15th September, 08:57 2025
Jun 18, 2025; Los Angeles, California, USA; Los Angeles Dodgers pitcher Emmet Sheehan (80) throws in the fourth inning against the San Diego Padres at Dodger Stadium. Mandatory Credit: Kirby Lee-Imagn ImagesJun 18, 2025; Los Angeles, California, USA; Los Angeles Dodgers pitcher Emmet Sheehan (80) throws in the fourth inning against the San Diego Padres at Dodger Stadium. Mandatory Credit: Kirby Lee-Imagn Images

The Monday MLB card features nine games with plenty of intriguing player and team props.

The game of the night takes place at Dodger Stadium as the Los Angeles Dodgers host the Philadelphia Phillies in a battle of division leaders.

We’ll break down three plays for the Monday action. Remember to monitor the odds throughout the day, as the props and totals market is constantly changing.

Here are the MLB best bets for Monday, September 15:

Best MLB plays today

Pirates F5 vs. Cubs (+110)

Reds F5 at Cardinals (+105)

Emmet Sheehan o 5.5 K’s (-112)

Pirates F5 vs. Cubs (+110 at DraftKings)

The Chicago Cubs head to PNC Park tonight to face division rival Pittsburgh Pirates, holding a 3.5-game edge over the San Diego Padres for the top NL Wild Card position.

The Cubs have been dreadful in road series openers the last three months in the first five innings, posting a 2-12 record. In nine of those games, Chicago has scored one run or less in the opening five frames.

Braxton Ashcraft takes the mound for Pittsburgh tonight. Ashcraft has pitched well for the Pirates of late, allowing three runs in the first five innings of his last five starts.

Former Pirate Jameson Taillon has put up a 4.99 ERA on the road, over 1.5 runs higher than at home this season.

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Reds F5 at Cardinals (+105 at DraftKings)

The Cincinnati Reds suffered a costly sweep at the hands of the Athletics in Sacramento this past weekend to fall 2.5 games behind the Mets for the final NL Wild Card spot.

The Reds head to St. Louis to face the Cardinals on Monday in an NL Central tilt. The Redbirds are back at home after avoiding a sweep in Sunday’s victory at Milwaukee.

Zack Littell has yet to lead through five innings in seven starts with the Reds Emmet Sheehan Over 5.5 Strikeouts (-112 at DraftKings)

The Dodgers and Phillies begin a three-game series at Chavez Ravine tonight as these teams could possibly see each other again in October.

Los Angeles right-hander Emmet Sheehan has been a strikeout machine of late, going Over his K prop in seven consecutive starts.

Sheehan has posted at least six strikeouts in five straight outings, capped off by a nine-strikeout performance against the Rockies.

Sheehan is forcing batters to a chase rate of 33%, which ranks in the 92nd percentile of the league. Phillies’ sluggers Bryce Harper, J.T. Realmuto, and Nick Castellanos all own chase rates above 30% on the season..

On the other side, Cardinals’ southpaw Matthew Liberatore is 2-5-2 in the first five innings of his last nine home starts.

The last time these pitchers faced off on August 29 in Cincinnati, the Reds fell to the Cardinals in extra innings, 7-5. In that game, Littell closed as a -135 favorite, but now he is a short road underdog.

In a battle of struggling pitchers, let’s back the Reds in the opening five innings at a plus price.

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Emmet Sheehan Over 5.5 Strikeouts (-112 at DraftKings)

The Dodgers and Phillies begin a three-game series at Chavez Ravine tonight as these teams could possibly see each other again in October.

Los Angeles right-hander Emmet Sheehan has been a strikeout machine of late, going Over his K prop in seven consecutive starts.

Sheehan has posted at least six strikeouts in five straight outings, capped off by a nine-strikeout performance against the Rockies.

Sheehan is forcing batters to a chase rate of 33%, which ranks in the 92nd percentile of the league. Phillies’ sluggers Bryce Harper, J.T. Realmuto, and Nick Castellanos all own chase rates above 30% on the season.


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