Report: Torn ACL to end 49ers DE Nick Bosa's season

Field Level Media|published: Mon 22nd September, 14:52 2025

NFL: Arizona Cardinals at San Francisco 49ers

Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) on the field during warm ups prior to a game against the Arizona Cardinals during the first half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

San Francisco 49ers star defensive end Nick Bosa's season is over with a torn ACL, multiple outlets reported Monday.

Bosa underwent testing after hurting his right knee during Sunday's victory over the Arizona Cardinals. Imaging showed a clean tear of the ligament, per ESPN.

The five-time Pro Bowl selection was injured in the first quarter while being double-teamed during an Arizona pass play. His knee bent awkwardly as he fell to the ground and he did not return to the contest, giving a thumbs down on his way to the sideline medical tent.

Bosa, 27, had two tackles and a forced fumble before departing. He has two sacks and 17 tackles in three games this season for the 49ers (3-0).

Bosa is in his seventh season with San Francisco. He was the Defensive Player of the Year in 2022 when he recorded a career-high 18.5 sacks. In 85 games (83 starts), he has 64.5 sacks, 91 tackles for loss, 168 quarterback hits, 278 tackles, 13 forced fumbles and two interceptions.

Veteran defensive Bryce Huff, acquired in a June trade with the Philadelphia Eagles, will take over starting duties as the 49ers prepare for Sunday's date with the visiting Jacksonville Jaguars (2-1).

--Field Level Media