Ohio State Buckeyes v Indiana Hoosiers Predictions (10/17/2026): Latest News, Picks & Market Movements

David Huber
Published: Thu Oct 15 2026
Reviewed By Paul Skidmore
Ohio State coach Ryan Day leads his team onto the field

The college football atmosphere will be lit this Saturday afternoon as the Ohio State Buckeyes travel to Bloomington to take on the Indiana Hoosiers in a high-stakes Big Ten Championship rematch. Both teams are currently ranked in the top 5 of the AP College Football poll and are looking to secure a spot in the College Football Playoff.

Traders who participate in college football prediction markets already know that the Buckeyes are favored by at least a field goal to break Indiana’s 19-game home winning streak this Saturday afternoon. After letting a “sure win” slip away against Texas earlier this year, Ohio State needs this victory on Saturday to remain on pace to make the CFP.

Ohio State v Indiana NCAAF Picks

The Indiana Hoosiers haven’t lost a football game since December 20th, 2024. The team currently holds the longest active winning streak in Division 1 collegiate football (22 straight wins). Our inclination is that the 39¢ per-contract price on Indiana to win Saturday’s game against Ohio State outright is severely underpriced… so much so that we’d still absorb the Hoosiers’ “yes” contracts even if they were priced at 45 cents per contract.

Forecasters who are confident that Indiana won’t falter should take the 3.5 points at even odds and feel content that they’re getting a great price on the Hoosiers winning their 23rd consecutive college football game. The defending national champions have the momentum as well as the status of the home team.

According to the Associated Press Top 25 Poll, Ohio State is ranked higher (at No. 4) than Indiana. However, poll observers will notice that Indiana has a lone first-place vote, while the Buckeyes lack any first-place votes. A road loss this Saturday afternoon could cause Ohio State to slip out of the top ten, while a win for Indiana will undoubtedly catapult the team into a guaranteed top-four ranking.

Favorite Picks: Ohio State v Indiana Winner – Indiana Hoosiers, NCAAF Point Spread – Hoosiers +3.5 points

Ohio State v Indiana NCAAF Latest News

The Ohio State backfield could be without its second and third-string running backs. Ja’Kobi Jackson is definitely OUT for Saturday afternoon’s contest in Bloomington. Isaiah West could also be on the sidelines, which means freshman Legend Bey may be backing up starting running back Bo Jackson.

The Indiana Hoosiers come into Saturday’s game with a clean bill of health. Starting quarterback Josh Hoover hasn’t thrown a single interception this year (but has completed 17 touchdown passes). Running back Turbo Richard is averaging more than eight yards per carry and could break down the Buckeyes’ defense by the fourth quarter.

There are currently three NCAA Division 1 college football teams ranked above these two Big Ten powerhouses going into the weekend: the Georgia Bulldogs, the Miami Hurricanes, and the Notre Dame Fighting Irish.

Ohio State v Indiana NCAAF Market Movement

We expect the Kalshi sports prediction market odds to shift in favor of Indiana before this Saturday afternoon’s kickoff in Bloomington, especially if Isaiah West is removed from the starting roster ahead of game time.

Indiana believers will want to secure the 39-cent contract prices ahead of time and take the +3.5 points at even odds before this market shifts. If past trends are any indication, there will be several million dollars traded on this game’s outcome before it kicks off. Sports fans across the country can tune in to FOX for live coverage from Memorial Stadium.

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