49ers overcome Brock Purdy's picks, shut down Panthers
Nov 24, 2025; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) makes a catch against the Carolina Panthers during the first half at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images Christian McCaffrey ran for 89 yards and a touchdown and the San Francisco 49ers overcame a horrible first-half stretch from quarterback Brock Purdy to beat the Carolina Panthers 20-9 on Monday night in Santa Clara, Calif.
The 49ers (8-4) did the job on defense to register back-to-back wins for the first time since September.
The Panthers (6-6) dropped into second place in the NFC South, a half-game behind the Tampa Bay Buccaneers, after managing just 230 yards of total offense.
McCaffrey had 24 carries and caught seven passes for 53 yards against his former team. Purdy completed 23 of 32 passes for 193 yards and a touchdown, and he was intercepted three times.
Panthers quarterback Bryce Young, who threw for a franchise-record 448 yards a week earlier at Atlanta, finished 18-for-29 for 169 yards. He had one TD pass and threw two interceptions.
Carolina defensive back Jaycee Horn picked off two passes, but he didn't play in the second half after sustaining a head injury.
McCaffrey ran 12 yards for a touchdown on San Francisco's first possession of the second half. The Panthers scored their first one touchdown with 49 seconds left in the third quarter on Young's 29-yard pass to Tetairoa McMillan.
After a personal-foul penalty was called against the 49ers on the extra-point kick, the Panthers opted to try for a two-point conversion, but Young's throw was incomplete and the score remained 17-9.
San Francisco responded with a 6 1/2-minute drive that resulted in Matt Gay's 29-yard field goal. When Carolina's Ryan Fitzgerald missed a field-goal attempt from 57 yards out with 2:41 left, the outcome was pretty much sealed.
The 49ers somehow led 10-3 at halftime, though a big reason for that was Carolina's 72 yards of total offense.
Purdy was intercepted three times in the first 21 minutes, twice by Horn and once by Mike Jackson. All the Panthers got out of those takeaways was a 25-yard field goal from Fitzgerald following the third Purdy turnover. On that possession, Carolina began at the San Francisco 33-yard line following Horn's 22-yard return.
Following Horn's first interception, the Panthers were set up at the San Francisco 16 before reaching the 1-yard line. Then Ji'Ayir Brown picked off Young's first-and-goal pass.
San Francisco, leading 7-0, was driving prior to the second interception, with Jackson corralling Purdy's underthrown pass in the end zone.
Following Carolina's field goal, the 49ers went 25 yards and got a 47-yard field goal from Gay with one minute left in the half. Gay, a veteran of seven NFL seasons, was in his first game for the 49ers since playing 10 games this year for the Commanders. Washington released him last week.
Before Purdy's pick-off problems, the 49ers quarterback opened the scoring with a 12-yard pass to Jauan Jennings, finishing a 15-play, 72-yard drive on the game's first possession.
--Field Level Media
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