Best MLB Bets Today: Top Picks & Props for Friday, May 16th
The weekend is here, and it’s a great day to bet on MLB. There are several intriguing matchups taking place across the country today, and quite a few bets worthy of your consideration. All of them, of course, can’t make my list of Best MLB Bets for Friday, May 16.
As always, line shop to make sure you get the best odds for your desired markets. But for our purposes, the odds will come from FanDuel (unless otherwise stated).
Chicago White Sox (+188) vs. Chicago Cubs (-1.5), o/u 12.5
I can’t figure out why the total on this game is so high. The Cubs are hitting .191 over the last week; the White Sox, .206. Shane Smith has been taking care of business when he takes the mound for the White Sox (2.08 ERA).
Cade Horton’s ERA is high (6.75), but he gave up just three runs in his one start. As long as Ryan Pressly doesn’t implode again, the final score should be well under 12.5.
Pick: Under 12.5
Claim your Special Pick via Code + First Time Deposit up to $250 in bonus!
T&Cs apply, 18+
Detroit Tigers (-1.5) vs. Toronto Blue Jays (+108), o/u 8.5
Here we have two teams that have been doing a great job making contact over the last week and scoring runs—both are averaging six runs per game over that span. With two pitchers who have a nasty habit of giving up home runs in the second-most home run-friendly park in baseball, we might see both teams push the total past 8.5.
Pick: Over 8.5
Claim your Special Pick via Code + First Time Deposit up to $250 in bonus!
T&Cs apply, 18+
Houston Astros (+154) vs. Texas Rangers (-185), o/u 8
Prop: Jose Altuve to hit a home run (+1000)
He only has four so far this season and is hitting just .250. But he’s faced Nathan Eovaldi in 52 at-bats, making 17 hits—nine of which went for extra bases, including seven home runs. While he hasn’t been crushing the ball this year, his history with Eovaldi gives this market value.
SGP: Adolis Garcia 1+ hit (-185), Marcus Semien 1+ hit (-180)
SGP Odds: +122
I’d like to think Lance McCullers Jr. will not be as bad in this outing as he was in his last. But even if he doesn’t give up seven runs in a third of an inning again, I’d expect the Rangers to make contact and get on base.
Garcia is hitting just .231 but is 3-for-8 lifetime vs. McCullers. Semien has been terrible at the plate this season (.176), but he has a solid history vs. McCullers (9-for-22). Since both have minus-money odds, I opted to combine them in a same-game parlay to boost the potential payout.
Claim your Special Pick via Code + First Time Deposit up to $250 in bonus!
T&Cs apply, 18+
Oakland Athletics (+1.5) vs. San Francisco Giants (-172), o/u 7.5
A’s pitcher JP Sears has been better on the road (3–1, 2.32 ERA, .200 opponent batting average) than at home. But Giants pitcher Logan Webb is practically unstoppable at home (2–0 in three starts, 0.44 ERA, .218 OBA).
The A’s are hitting well over the past week (.277 BA), while the Giants have not been as fortunate (.238). But with how well both starters are pitching right now, I don’t expect to see too many hits—and even fewer runs.
Pick: Under 7.5
Claim your Special Pick via Code + First Time Deposit up to $250 in bonus!
T&Cs apply, 18+
Related
Three UFC Fighters Facing Uncertain Futures After Mexico
Best 2026 MLB Futures Bets for the NL West
Lu Dort’s Antics Outshine Big Win for Oklahoma City Thunder
Why Tiger Woods Playing the Masters Seems Unlikely
Big Ten March Madness Contenders Ranked by Analytics
- Friday NBA Picks: Pistons vs Cavs, Nuggets vs Thunder, and More
- NL Central 2026 Futures Picks: Brewers, Pirates and Cardinals Bets
- Thursday Feb. 26th NBA Best Bets: Top Basketball Betting Predictions Today
- Three Best College Basketball Bets For Feb. 25th's Slate
- Three Best NBA Bets for Tuesday Feb 24th's Slate
- NL East Future Betting Picks: Season Win Totals and Division Predictions
- Monday College Basketball Betting Picks for Houston-Kansas and Louisville-UNC




