The Most Interesting NFL Week 1 Kalshi Prediction Markets Before Sunday

The NFL is back with a jam packed Week 1 featuring plenty of star-studded teams.

This first week of the season provides NFL fans with an opportunity to make their first predictions of the entire season. Kalshi, a popular prediction market that allows users to buy and sell contracts of real-world outcomes like NFL games, has plenty of markets that football fans should know about ahead of Week 1.

Let’s take a look at a few fun prediction markets before this week kicks off.

New England Patriots vs. Seattle Seahawks Anytime Touchdown Scorer

The football season kicks off with the final two teams from last season as the Patriots and Seahawks get an immediate Super Bowl rematch in Week 1.

Both of these rosters improved over the offseason. But a notable difference is Seattle’s run game. The Seahawks lost Super Bowl MVP Kenneth Walker to the Kansas City Chiefs in free agency. So in the 2026 NFL Draft, Seahawks general manager John Schnieder selected running back Jadarian Price at No. 32 overall out of Notre Dame.

Without Zach Charbonnet (ACL recovery), the Seahawks should see what they have in their young running back early in his rookie season.

Kalshi gives Price a 40% chance of scoring a touchdown during Week 1, and a 40¢ contract would return just over twice the investment.

Los Angeles Rams’ Defense To Score First TD vs. San Francisco 49ers in Australia

Two California teams will face off on Thursday in the league’s first game down under.

The Rams had an incredible offseason, trading for back-to-back Defensive Player of the Year Myles Garrett after he broke the single-season sack record last year. After that news, the Rams officially brought back Aaron Donald on a one-year deal, but he has already been ruled out for Week 1.

Without question, the Rams will feature one of the best defensive lines in football. But they also picked up superstar cornerback Trent McDuffie in a spring trade with the Kansas City Chiefs.

Can they use all of this defensive momentum into scoring the first touchdown in Australia? Especially against a Niners team that lost Brandon Aiyuk and brought back an aging Deebo Samuel?

The 49ers won’t be bad this season. But couldn’t you imagine an offensive flub in Australia to start the game? It’s a fun prediction to make and has a 14% chance of happening, which would return over a triple payout on Kalshi.