NFL Week 16 Best Betting Picks, Predictions December 22, 2024

With two games Saturday, there are 12 NFL games on the Sunday slate for Week 16. With approximately 400 markets available for each game (374-424 per game at BetRivers), we are talking about around 4800 possible wagers you could make today. But which ones are the best?

We’ve done a deep dive into today’s games and consider the following the best NFL bets of the day.

The following are not in any particular order. Odds listed will be from FanDuel unless otherwise stated. But we recommend line shopping to make sure you get the best odds for your desired market.

Giants vs. Falcons: UNDER 43.5 at -118

The big story here is Kirk Cousins getting benched by the Falcons for rookie Michael Penix Jr. He was a gunslinger in college, so maybe he explodes and has a big day. If they were playing the Jaguars league-worst pass defense, that might happen.

However, the Giants pass defense ranks No. 6 in the league, so it would be unrealistic to count on Penix Jr. for much. But the Falcons probably know this already anyway and will lean hard on Bijan Robinson and Tyler Allgeier in the run game. (20.9 points).

The Giants are averaging a league-worst 14.9 per game and will be lucky to do that with Drew Lock back at quarterback. Take the UNDER.

Browns vs. Bengals: Bengals -9 at -110 (DraftKings)

Nine points is a large spread to cover, but we have two offenses on totally different trajectories. Chase Brown is coming into his own as a running back. Joe Burrow and Ja’Marr Chase have the Cincinnati passing game humming.

But the Cleveland offense is going nowhere fast. The run game is squeaking out 92 yards a game this season, and the Browns have benched Jameis Winston for Dorian Thompson-Robinson. DTR has completed 44% of his passes this season and 51% during his short career.

The Bengals' defense has had issues this season, but they’ll handle the dysfunctional Browns offense without too much trouble. Cleveland’s defense is not bad, but it will be on the field way too often to be effective in the second half.

It’s a big spread, but the Bengals will cover.

Rams vs. Jets: Puka Nacua, OVER 85.5 Receiving Yards at -115 (BetMGM)

It will be a cold but sunny day, so the weather will not be a concern. While the Jets' defense still ranks well (No. 5), this is a team just looking to finish the season. It’s not playing nearly as well as you’d think (an average of 263.7 ypg allowed over their last three).

Puka Nacua has become the No. 1 for Matthew Stafford. He’s averaged 11 targets per game over the last six with 49 total receptions. Of those games, he went over 100 yards in three and over 85.5 in five.

With the Rams looking to stay on top of the division, Stafford will target his favorite receiver early and often. He might have 100 by halftime. Take the OVER.

Buccaneers vs. Cowboys: Mike Evans, OVER 78.5 Receiving Yards at -115 (BetMGM)

Injuries have limited Evans this season, but despite only playing in 11 games, he is in good shape to clear 1,000 yards receiving for the 11th time in his career. He’s been coming on strong over his last four games with 100+ efforts and 68 and 69 yards in the other two.

Dallas has been giving up just under 160 yards per game to wide receivers this season (No. 25). Baker Mayfield will look to make the most of his superstar wide receiver against such a generous secondary. Take the OVER.