Rams vs Seahawks Thursday Night Football Week 16 Betting Picks

The Seattle Seahawks will host the Los Angeles Rams, with the NFC West on the line, on Thursday Night Football. The Rams and Seahawks both come into this game with an 11-3 record. Los Angeles barely grabbed a win in their first matchup of the season.

It’s fair to suggest the Rams were lucky in their first game. The Seahawks outgained them by over 150 yards in that game. They also had over twice as many first downs, and they were drastically better on third down.

The Rams won in two aspects of this game, but they’re arguably the two most important. First, Sam Darnold threw four interceptions, giving Los Angeles a massive edge in turnovers (4:1). The Seahawks also converted only 25% of their red zone drives into touchdowns compared to 75% for the Rams.

Darnold’s thrown 11 interceptions this season, with nearly 40% of those coming against Los Angeles. The Rams also scored two relatively easy touchdowns off those four interceptions, giving them a significant edge.

I expect Darnold and the Seahawks to have an edge at home. He’s only thrown 3 interceptions in Seattle this season, and I wouldn’t expect the same number of giveaways in this game. The Seahawks consistently found offensive success in their first matchup, and that should be the case without the turnovers in Week 16.

Although I do believe Seattle is going to have an edge from playing at home in this game, the Rams have traveled extremely well this season. They lead the NFL with a +12.7 average scoring margin on the road. It’s 1.3 points higher than the second-best team, which happens to be Seattle.

The Rams have had some issues on the road, though. They lost to the Philadelphia Eagles early in the season, although that isn’t a bad loss by any stretch. More recently, Los Angeles lost as a massive favorite to the Carolina Panthers.

We’ve seen the Rams bounce back from that game, but this is going to be arguably their most difficult game of the regular season.

In a game with the division on the line, including potentially the top overall seed in the NFL, I prefer the home team as a small underdog. I’m expecting fewer turnovers in this game, giving the edge to the Seahawks.

Where to Bet: Seattle Seahawks +1.5 spread | -122 at FanDuel Sportsbook

2025 NFL Season Betting Record: 22-33