Cardinals QB Kyler Murray (foot) not practicing Wednesday

Field Level Media|published: 10/08/2025, 2:02pm EDT

Oct 5, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) makes a throw against the Tennessee Titans during the fourth quarter at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images

Arizona Cardinals quarterback Kyler Murray did not practice on Wednesday due to a foot injury.

Head coach Jonathan Gannon said Murray is taking it "day by day" heading into Sunday's game at Indianapolis.

Murray briefly exited last weekend's loss to the Tennessee Titans, missing three snaps before returning to the field.

Murray, 28, has not missed a game since sitting out Weeks 1-9 in 2023 while recovering from surgery for a torn ACL.

Veteran Jacoby Brissett relieved Murray against the Titans and would be the next man up against the Colts (4-1).

"If he's gotta play, he's gotta play," Gannon said of Brissett, 32.

The Cardinals (2-3) have lost three straight games, all of them on game-ending field goals.

Murray has completed 68.3 percent of his passes for 962 yards with six touchdowns and three interceptions in five starts this season. He has rushed for 173 yards and one score.

--Field Level Media