Louisville RB Isaac Brown exits with injury against Virginia Tech

Field Level Media|published: Sat 1st November, 18:23 2025

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals running back Isaac Brown (1) runs the ball for a touchdown against the Virginia Tech Hokies during the first quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

Louisville's Isaac Brown was helped away from the Virginia Tech sideline with 5:40 left in the game.

Brown was grabbing at the back of his right leg after a 10-yard carry that was negated by a holding penalty.

Brown has 130 yards on 16 carries with a 52-yard TD run. He leads the nation with an 8.7 rushing average.

Brown has not missed a game this season, but he has been limited by injuries in three games. He has five 100-yard games this season; the Cardinals are 5-0 in those games.

On October 25, he rushed for a season-high 205 yards against Boston College.

--Field Level Media

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